Dihydrofolate Reductase (DHFR) Antibody

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.

Target	Dihydrofolate Reductase (DHFR)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 135-164 amino acids from the C-terminal region of mouse DHFR.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00375 (UniProt, ExPASy)
UniProt Secondary AC	P70693, Q61485, Q61487, Q61579
UniProt Entry Name	DYR_MOUSE
KEGG	mmu:13361
String	10090.ENSMUSP00000022218
Molecular Weight	Calculated MW: 21.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dihydrofolate Reductase (DHFR)

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