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Glycogen Synthase Kinase-3 Beta (GSK3B) Antibody
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Catalogue No: abx033884
Price:
US$290.00
(Size: 80 µl)
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GSK3B, a member of the Ser/Thr protein kinase family, participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. GSK3B phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. The protein is inhibited when phosphorylated by AKT1 or ILK1. Expressed is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney.
Research Articles on Glycogen Synthase Kinase-3 Beta (GSK3B)
| Target | Glycogen Synthase Kinase-3 Beta (GSK3B) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of Human GSK3 beta (GSK3B). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by Protein A affinity chromatography, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49841 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DN89, Q9BWH3, Q9UL47 |
| UniProt Entry Name | GSK3B_HUMAN |
| HGNC | 4617 |
| KEGG | hsa:2932 |
| String | 9606.ENSP00000324806 |
| Molecular Weight | Calculated MW: 46.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat GSK3B. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |