Human Histidyl-tRNA synthetase (HARS) Protein

Human Histidyl-tRNA synthetase (HARS) Enzyme is a recombinant enzyme produced in baculovirus. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

Target	Histidyl-tRNA synthetase (HARS)
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	Insect
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Purity	> 90% (SDS-PAGE)
Storage	Store below -18°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12081 (UniProt, ExPASy)
UniProt Secondary AC	B4DHQ1, B4DY73, D6REN6, J3KNE5
UniProt Entry Name	SYHC_HUMAN
KEGG	hsa:3035
String	9606.ENSP00000425634
Activity	Not tested
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Histidyl-tRNA synthetase (HARS)

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