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Histamine N-Methyltransferase (HNMT) Antibody
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Catalogue No: abx001961
Price:
US$203.00
(Size: 20 µl)
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HNMT Antibody is a Rabbit Polyclonal antibody against HNMT. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Research Articles on Histamine N-Methyltransferase (HNMT)
| Target | Histamine N-Methyltransferase (HNMT) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human HNMT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P50135 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9J3, Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6 |
| UniProt Entry Name | HNMT_HUMAN |
| Gene Symbol | HNMT |
| GeneID | 3176 |
| NCBI Accession | NP_008826.1 |
| KEGG | hsa:3176 |
| String | 9606.ENSP00000280097 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 33 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |