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Integrin Alpha IIb / CD41 (ITGA2B) Antibody
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Catalogue No: abx015898
Price:
US$420.50
(Size: 100 µl)
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ITGA2B encodes integrin alpha chain 2b.Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation.Mutations that interfere with this role result in thrombasthenia.In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Research Articles on Integrin Alpha IIb / CD41 (ITGA2B)
| Target | Integrin Alpha IIb / CD41 (ITGA2B) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08514 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RCY8, O95366, Q14443, Q17R67 |
| UniProt Entry Name | ITA2B_HUMAN |
| Gene Symbol | ITGA2B |
| GeneID | 3674 |
| OMIM | 187800 |
| HGNC | 6138 |
| KEGG | hsa:3674 |
| Ensembl | ENSG00000005961 |
| String | 9606.ENSP00000262407 |
| Molecular Weight | 113.4 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |