J9

J9 is a small molecule. J9, in combination with dexamethasone inhibits cell growth in T-cell acute lymphoblastic leukemia (T-ALL) through the upregulation of the glucocorticoid receptor. Patients can develop glucocorticoid resistance rendering the treatment ineffective. J9 and its mechanism of action provides a useful strategy for overcoming the resistance. The EC50 of J9 in combination with dexamethasone is 28 uM. J9 alone was less toxic.

Target	J9
Origin	Synthetic
Form	Solid
Purity	0.999
Storage	Store at -20 °C.
Molecular Weight	212.26 g/mol
Molecular Formula	C12H12N4
SMILES	NC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1
Availability	Shipped within 5-12 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on J9

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