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Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibody
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Catalogue No: abx000638
Price:
US$203.00
(Size: 20 µl)
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MAP2K2 Antibody is a Rabbit Polyclonal antibody against MAP2K2. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Research Articles on Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2)
| Target | Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P36507 (UniProt, ExPASy) |
| UniProt Entry Name | MP2K2_HUMAN |
| Gene Symbol | MAP2K2 |
| GeneID | 5605 |
| NCBI Accession | NP_109587.1 |
| KEGG | hsa:5605 |
| String | 9606.ENSP00000262948 |
| Molecular Weight | Calculated MW: 44 kDa Observed MW: 53 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |