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MAPK/ERK Kinase Kinase 6 (MEKK6) Antibody
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Catalogue No: abx033759
Price:
US$290.00
(Size: 80 µl)
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Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK6 activates the JNK, but not ERK or p38 kinase pathways.
Research Articles on MAPK/ERK Kinase Kinase 6 (MEKK6)
| Target | MAPK/ERK Kinase Kinase 6 (MEKK6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1028-1058 amino acids from the C-terminal region of human MEKK6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95382 (UniProt, ExPASy) |
| UniProt Secondary AC | A2ACE8, A2VDG4, A2VDG5, Q59HF4, Q5SSD4, Q75PK3, Q96B75 |
| UniProt Entry Name | M3K6_HUMAN |
| NCBI Accession | NP_004663.3 |
| KEGG | hsa:9064 |
| String | 9606.ENSP00000419591 |
| Molecular Weight | Calculated MW: 143 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |