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Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody
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Catalogue No: abx001811
Price:
US$217.50
(Size: 20 µl)
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RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3. EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).
Research Articles on Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3)
| Target | Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95398 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K2G5, E7EQC8, O95634, Q8WVN0 |
| UniProt Entry Name | RPGF3_HUMAN |
| Gene Symbol | RAPGEF3 |
| GeneID | 10411 |
| OMIM | 606057 |
| NCBI Accession | NP_001092002.1 |
| HGNC | 16629 |
| KEGG | hsa:10411 |
| Ensembl | ENSG00000079337 |
| String | 9606.ENSP00000395708 |
| Molecular Weight | Calculated MW: 104 kDa Observed MW: 104 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 0.35 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |