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72 kDa Inositol Polyphosphate 5-Phosphatase (INPP5E) Antibody
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Catalogue No: abx003688
Price:
US$246.50
(Size: 20 µl)
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INPP5E Antibody is a Rabbit Monoclonal antibody against INPP5E. The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.
Research Articles on 72 kDa Inositol Polyphosphate 5-Phosphatase (INPP5E)
| Target | 72 kDa Inositol Polyphosphate 5-Phosphatase (INPP5E) |
| Clonality | Monoclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CD81. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9NRR6 (UniProt, ExPASy) |
| UniProt Secondary AC | Q15734, Q6PIV5 |
| UniProt Entry Name | INP5E_HUMAN |
| GeneID | 56623 |
| String | 9606.ENSP00000360777 |
| Molecular Weight | Calculated MW: 26 kDa Observed MW: 22 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 0.05% BSA, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |