The Tyrosine-Protein Kinase ABL1 (ABL1) protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns Tyrosine-Protein Kinase ABL1 (ABL1) into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and Tyrosine-Protein Kinase ABL1 (ABL1) genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed Tyrosine-Protein Kinase ABL1 (ABL1) tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for Tyrosine-Protein Kinase ABL1 (ABL1). The Tyrosine-Protein Kinase ABL1 (ABL1) gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11./ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from Tyrosine-Protein Kinase ABL1 (ABL1). The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.
Target |
Tyrosine-Protein Kinase ABL1 (ABL1) |
Clonality |
Monoclonal |
Reactivity |
Human |
Tested Applications |
ELISA |
Host |
Mouse |
Recommended dilutions |
ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Purified recombinant fragment of ABL1 (aa577-650) expressed in E. coli. |
Isotype |
IgG1 |
Form |
Liquid |
Purification |
Unpurified ascites. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P00519 (UniProt,
ExPASy)
|
UniProt Secondary AC |
A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09 |
UniProt Entry Name |
ABL1_HUMAN |
Gene Symbol |
ABL1 |
GeneID |
25
|
OMIM |
189980
|
HGNC |
76
|
KEGG |
hsa:25
|
Ensembl |
ENSG00000097007 |
String |
9606.ENSP00000361423
|
Molecular Weight |
122 kDa |
Buffer |
Ascitic fluid containing 0.03% sodium azide. |
Concentration |
Not determined. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Tyrosine-Protein Kinase ABL1 (ABL1)