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Activated CDC42 Kinase 1 (ACK1) Antibody
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Catalogue No: abx033628
Price:
US$326.25
(Size: 80 µl)
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ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Research Articles on Activated CDC42 Kinase 1 (ACK1)
| Target | Activated CDC42 Kinase 1 (ACK1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 934-964 amino acids from the C-terminal region of human ACK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q07912 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6ZMQ0, Q8N6U7, Q96H59 |
| UniProt Entry Name | ACK1_HUMAN |
| NCBI Accession | NP_001010938.1 NP_005772.3 |
| KEGG | hsa:10188 |
| String | 9606.ENSP00000371341 |
| Molecular Weight | Calculated MW: 115 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow TNK2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |