Cytoplasmic Aconitate Hydratase (ACO1) Antibody

ACO1 Antibody is a Rabbit Monoclonal antibody against ACO1. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

Target	Cytoplasmic Aconitate Hydratase (ACO1)
Clonality	Monoclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Aconitase 1 (ACO1).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21399 (UniProt, ExPASy)
UniProt Secondary AC	D3DRK7, Q14652, Q5VZA7
UniProt Entry Name	ACOC_HUMAN
Gene Symbol	ACO1
GeneID	48
KEGG	hsa:48
String	9606.ENSP00000309477
Enzyme Commission Number	EC 4.2.1.3 EC 4.2.1
Molecular Weight	Calculated MW: 98 kDa Observed MW: 100 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytoplasmic Aconitate Hydratase (ACO1)

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