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Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody
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Catalogue No: abx148388
Price:
US$406.00
(Size: 100 µg)
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Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody is a Rabbit Polyclonal antibody for the detection of ATF6. Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N (9) -CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6)
| Target | Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | activating transcription factor 6 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P18850 (UniProt, ExPASy) |
| UniProt Secondary AC | O15139, Q5VW62, Q6IPB5, Q9UEC9 |
| UniProt Entry Name | ATF6A_HUMAN |
| Gene Symbol | ATF6 |
| GeneID | 22926 |
| OMIM | 605537 |
| HGNC | 791 |
| KEGG | hsa:22926 |
| Ensembl | ENSG00000118217 |
| String | 9606.ENSP00000356919 |
| Molecular Weight | Observed MW: 50 kDa，100 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |