Actin Like 7A (ACTL7A) Antibody

ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.

Target	Actin Like 7A (ACTL7A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 41-67 amino acids from the N-terminal region of human ACTL7A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y615 (UniProt, ExPASy)
UniProt Secondary AC	B2RC83, Q5JSV0
UniProt Entry Name	ACL7A_HUMAN
Gene Symbol	ACTL7A
String	9606.ENSP00000334300
Molecular Weight	Calculated MW: 48.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey ACTL7A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Actin Like 7A (ACTL7A)

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