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Alpha Actinin 4 (ACTN4) Antibody
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Catalogue No: abx033682
Price:
US$326.25
(Size: 80 µl)
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This protein is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and is thought to be involved in metastatic processes. Mutations in the gene encoding this protein have been associated with focal and segmental glomerulosclerosis.
Research Articles on Alpha Actinin 4 (ACTN4)
| Target | Alpha Actinin 4 (ACTN4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 192-220 amino acids from the N-terminal region of human ACTN4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43707 (UniProt, ExPASy) |
| UniProt Secondary AC | A4K467, D6PXK4, O76048 |
| UniProt Entry Name | ACTN4_HUMAN |
| Gene Symbol | ACTN4 |
| KEGG | hsa:81 |
| String | 9606.ENSP00000252699 |
| Molecular Weight | Calculated MW: 105 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Chicken ACTN4. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |