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Activin A Receptor Type 2B (ACVR2B) Antibody
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Catalogue No: abx033182
Price:
US$326.25
(Size: 80 µl)
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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3 to 4-fold higher affinity for the ligand than activin A type II receptor.
Research Articles on Activin A Receptor Type 2B (ACVR2B)
| Target | Activin A Receptor Type 2B (ACVR2B) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide selected from the N-terminal region of human ACVR2B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13705 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4VAV0 |
| UniProt Entry Name | AVR2B_HUMAN |
| NCBI Accession | NP_001097.2 |
| KEGG | hsa:93 |
| String | 9606.ENSP00000340361 |
| Molecular Weight | Calculated MW: 57.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |