Aminoacylase 1 (ACY1) Antibody
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Price:
US$203.00
(Size: 20 µl)
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ACY1 Antibody is a Rabbit Polyclonal antibody against ACY1. This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
Target |
Aminoacylase 1 (ACY1) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
WB, IF/ICC |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-408 of human ACY1. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q03154 (UniProt,
ExPASy)
|
UniProt Secondary AC |
C9J6I6, C9J9D8, C9JWD4 |
UniProt Entry Name |
ACY1_HUMAN |
Gene Symbol |
ACY1 |
GeneID |
95
|
NCBI Accession |
NP_001185824.1
|
KEGG |
hsa:95
|
String |
9606.ENSP00000384296
|
Molecular Weight |
Calculated MW: 46 kDa Observed MW: 46 kDa |
Buffer |
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
Concentration |
> 0.2 mg/ml |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Aminoacylase 1 (ACY1)