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Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody
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Catalogue No: abx020064
Price:
US$406.00
(Size: 100 µg)
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Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody is a Rabbit Polyclonal antibody for the detection of ADAM17. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
Research Articles on Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17)
| Target | Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ADAM metallopeptidase domain 17 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P78536 (UniProt, ExPASy) |
| UniProt Secondary AC | O60226 |
| UniProt Entry Name | ADA17_HUMAN |
| Gene Symbol | ADAM17 |
| GeneID | 6868 |
| OMIM | 603639 |
| HGNC | 195 |
| KEGG | hsa:6868 |
| Ensembl | ENSG00000151694 |
| String | 9606.ENSP00000309968 |
| Enzyme Commission Number | EC 3.4.24.86 |
| Molecular Weight | Observed MW: 115 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |