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Adiponectin Receptor 1 (ADIPOR1) Antibody
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Catalogue No: abx001271
Price:
US$203.00
(Size: 20 µl)
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ADIPOR1 Antibody is a Rabbit Polyclonal antibody against ADIPOR1. Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPARå. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.
Research Articles on Adiponectin Receptor 1 (ADIPOR1)
| Target | Adiponectin Receptor 1 (ADIPOR1) |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-59 of human Adiponectin Receptor 1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96A54 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KMB0, Q53HS7, Q53YY6, Q9Y360 |
| UniProt Entry Name | PAQR1_HUMAN |
| Gene Symbol | ADIPOR1 |
| GeneID | 51094 |
| NCBI Accession | NP_057083.2 |
| KEGG | hsa:51094 |
| String | 9606.ENSP00000341785 |
| Molecular Weight | Calculated MW: 43 kDa Observed MW: 43 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |