Alanine--TRNA Ligase, Cytoplasmic (AARS1) Antibody

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes.Class II tRNA synthases evolved early in evolution and are highly conserved.This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein.tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons.They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.

Target	Alanine--TRNA Ligase, Cytoplasmic (AARS1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 61-91 amino acids from the N-terminal region of human AlaRS (AARS).
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49588 (UniProt, ExPASy)
UniProt Secondary AC	A6NF14, B4DR45, Q53GV7, Q96FA0
UniProt Entry Name	SYAC_HUMAN
KEGG	hsa:16
String	9606.ENSP00000261772
Molecular Weight	Calculated MW: 107 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Drosophila and C. elegans AARS1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alanine--TRNA Ligase, Cytoplasmic (AARS1)

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