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Programmed Cell Death 6-Interacting Protein (PDCD6IP) Antibody
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Catalogue No: abx001822
Price:
US$203.00
(Size: 20 µl)
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ALIX Antibody is a Rabbit Polyclonal antibody against ALIX. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Research Articles on Programmed Cell Death 6-Interacting Protein (PDCD6IP)
| Target | Programmed Cell Death 6-Interacting Protein (PDCD6IP) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALIX / PDCD6IP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8WUM4 (UniProt, ExPASy) |
| UniProt Secondary AC | C5MQH7, E9PFU1, Q6NUS1, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5 |
| UniProt Entry Name | PDC6I_HUMAN |
| Gene Symbol | PDCD6IP |
| GeneID | 10015 |
| OMIM | 608074 |
| NCBI Accession | NP_037506.2 |
| HGNC | 8766 |
| KEGG | hsa:10015 |
| Ensembl | ENSG00000170248 |
| String | 9606.ENSP00000411825 |
| Molecular Weight | Calculated MW: 96 kDa Observed MW: 105 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 3.76 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |