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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody
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Catalogue No: abx146588
Price:
US$406.00
(Size: 100 µg)
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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody is a Rabbit Polyclonal antibody for the detection of ALPL. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL (Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa (PMID:18724009). ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H (Endo H) -sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol (GPI) (PMID:10839996).This antibody can bind the four mentioned alkaline phosphatases.
Research Articles on Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL)
| Target | Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | alkaline phosphatase, liver/bone/kidney |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P05186 (UniProt, ExPASy) |
| UniProt Entry Name | PPBT_HUMAN |
| Gene Symbol | ALPL |
| GeneID | 249 |
| OMIM | 146300 |
| HGNC | 438 |
| KEGG | hsa:249 |
| Ensembl | ENSG00000162551 |
| String | 9606.ENSP00000363973 |
| Molecular Weight | Observed MW: 45-60 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
