Vitamin E (Alpha-Tocopherol)

(+)-α-Tocopherol is a small molecule. Tocopherols are methyl-substituted hydroxychromans with a phytyl side chain. This product is semisynthetic. It is isolated from naturally occurring α-tocopherol found in vegetable oil. It is prepared using a by-product of the vegetable oil process called vegetable oil distillate (VOD) as its raw material. Soybean oil is used as a solvent in this process. α-Tocopherol is a powerful inhibitor of the proliferation of estrogen receptor positive and estrogen receptor negative human breast cancer cell lines in a dose dependent manner in vitro. Treatment at 15 µg/ml for 24 hours inhibited MDA-MB-435 cell proliferation by 71%. However, cells treated with this level of α-tocopherol exhibited reduced viability (81% vs. 96% for control cells). This product has been shown to interact with cytosolic Protein Kinase C in vascular smooth muscle cells. A review of various published research studies suggests that this product may help ward off heart attacks. α-Tocopherol is carried with LDLs and shields LDL from oxidation by free radicals. This protection leads to a decrease in LDL oxidation, which is a major cause in triggering artery stenosis. Artery blockage is due to immune cells engulfing oxidized LDL, which causes swelling and accumulation of fatty masses within the artery walls. Vitamin E may help prevent this. Isolation and analysis of tocopherols can be easily performed by a simple acetone extraction followed by HPLC.6 A C18 ODS2 column is packed with 3 µm particles and a methanol : water (99:1) mobile phase is used for isolation, resulting in detection and easy measurement of α-, δ-, and γ-tocopherol peaks. Fluorescence detection was performed with 290 nm excitation and 330 nm emission wavelengths.

Target	Vitamin E (Alpha-Tocopherol)
Conjugation	Unconjugated
Storage	Store at room temperature.
Molecular Weight	430.7 Da
Molecular Formula	C29H50O2
Buffer	Not applicable.
CAS Number	59-02-9
Biological Activity	Type VI, approx. 1000 IU/g
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Vitamin E (Alpha-Tocopherol)

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