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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody
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Catalogue No: abx028274
Price:
US$326.25
(Size: 80 µl)
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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody is a rabbit polyclonal antibody for ALPL. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Research Articles on Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL)
| Target | Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/500, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 217-246 amino acids from the Central region of human ALPL. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05186 (UniProt, ExPASy) |
| UniProt Entry Name | PPBT_HUMAN |
| NCBI Accession | NP_000469.3 NP_001120973.2 NP_001170991.1 |
| KEGG | hsa:249 |
| String | 9606.ENSP00000363973 |
| Molecular Weight | Calculated MW: 57.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Concentration | 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |