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Alsin (ALS2) Antibody
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Catalogue No: abx005380
Price:
US$217.50
(Size: 20 µl)
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ALS2 Antibody is a Rabbit Polyclonal antibody against ALS2. The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on Alsin (ALS2)
| Target | Alsin (ALS2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 260-429 of human ALS2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96Q42 (UniProt, ExPASy) |
| UniProt Secondary AC | Q53TT1, Q53TV2, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9 |
| UniProt Entry Name | ALS2_HUMAN |
| Gene Symbol | ALS2 |
| GeneID | 57679 |
| NCBI Accession | NP_065970.2 |
| KEGG | hsa:57679 |
| String | 9606.ENSP00000264276 |
| Molecular Weight | Calculated MW: 184 kDa Observed MW: 184 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |