Androgen Receptor (AR) Antibody

Androgen receptor has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription.

Target	Androgen Receptor (AR)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10275 (UniProt, ExPASy)
UniProt Secondary AC	A0A0B4J1T2, A2RUN2, B1AKD7, C0JKD3, C0JKD4, E7EVX6, Q9UD95
UniProt Entry Name	ANDR_HUMAN
KEGG	hsa:367
String	9606.ENSP00000363822
Molecular Weight	Calculated MW: 99.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Pig and Monkey AR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Androgen Receptor (AR)

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