Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody

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Catalogue No: abx001587
Price: US$217.50
(Size: 20 µl)

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Western blot analysis of various lysates using APBB1 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody

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Datasheet SDS
APBB1 Antibody is a Rabbit Polyclonal antibody against APBB1. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Target Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O00213 (UniProt, ExPASy)
UniProt Entry Name APBB1_HUMAN
Gene Symbol APBB1
GeneID 322
NCBI Accession NP_663722.1
KEGG hsa:322
String 9606.ENSP00000477213
Molecular Weight Calculated MW: 77 kDa
Observed MW: 63 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1)
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