Beta-Amyloid Precursor Protein (APP) Antibody

APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Target	Beta-Amyloid Precursor Protein (APP)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 29-61 amino acids from the N-terminal region of human APP.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05067 (UniProt, ExPASy)
NCBI Accession	NP_000475.1 NP_001129488.1 NP_001129601.1 NP_001129602.1 NP_001129603.1 NP_001191230.1 NP_001191231.1 NP_001191232.1 NP_958816.1 NP_958817.1
Molecular Weight	Calculated MW: 86.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey APP.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Beta-Amyloid Precursor Protein (APP)

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