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Beta-Amyloid Precursor Protein (APP) Antibody
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Catalogue No: abx032791
Price:
US$326.25
(Size: 80 µl)
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APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Research Articles on Beta-Amyloid Precursor Protein (APP)
| Target | Beta-Amyloid Precursor Protein (APP) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 29-61 amino acids from the N-terminal region of human APP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05067 (UniProt, ExPASy) |
| NCBI Accession | NP_000475.1 NP_001129488.1 NP_001129601.1 NP_001129602.1 NP_001129603.1 NP_001191230.1 NP_001191231.1 NP_001191232.1 NP_958816.1 NP_958817.1 |
| Molecular Weight | Calculated MW: 86.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey APP. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |