Aprataxin (APTX) Antibody

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Catalogue No: abx240097
Price: US$406.00
(Size: 100 µg)

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Datasheet SDS
Aprataxin (APTX) Antibody is a Rabbit Polyclonal antibody for the detection of APTX.

APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.

Target Aprataxin (APTX)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen aprataxin
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC Q7Z2E3 (UniProt, ExPASy)
UniProt Entry Name APTX_HUMAN
Gene Symbol APTX
GeneID 54840
KEGG hsa:54840
String 9606.ENSP00000400806
Molecular Weight Observed MW: 40 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note This product is for research use only.
Research Articles on Aprataxin (APTX)


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