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Arrestin Beta 2 (ARRB2) Antibody
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Catalogue No: abx001085
Price:
US$203.00
(Size: 20 µl)
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ARRB2 Antibody is a Rabbit Polyclonal antibody against ARRB2. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. ARRB2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for ARRB2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Arrestin Beta 2 (ARRB2)
| Target | Arrestin Beta 2 (ARRB2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ARRB2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P32121 (UniProt, ExPASy) |
| UniProt Entry Name | ARRB2_HUMAN |
| Gene Symbol | ARRB2 |
| GeneID | 409 |
| OMIM | 107941 |
| NCBI Accession | NP_004304.1 |
| HGNC | 712 |
| KEGG | hsa:409 |
| Ensembl | ENSG00000141480 |
| String | 9606.ENSP00000403701 |
| Molecular Weight | Calculated MW: 46 kDa Observed MW: 46 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |