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Achaete-Scute Homolog 1 (ASCL1) Antibody
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Catalogue No: abx031440
Price:
US$326.25
(Size: 80 µl)
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ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.
Research Articles on Achaete-Scute Homolog 1 (ASCL1)
| Target | Achaete-Scute Homolog 1 (ASCL1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human ASCL1 (Achaete-scute homolog 1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P50553 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K3C4, Q9BQ30 |
| UniProt Entry Name | ASCL1_HUMAN |
| NCBI Accession | NP_004307.2 |
| KEGG | hsa:429 |
| String | 9606.ENSP00000266744 |
| Molecular Weight | Calculated MW: 25.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat ASCL1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |