Agouti-Signaling Protein (ASIP) Antibody

ASIP Antibody is a Rabbit Polyclonal antibody against ASIP. In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may affect the quality of hair pigmentation, act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, play a role in neuroendocrine aspects of melanocortin action, and have a functional role in regulating lipid metabolism in adipocytes.

Target	Agouti-Signaling Protein (ASIP)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	IHC
Host	Rabbit
Recommended dilutions	IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42127 (UniProt, ExPASy)
UniProt Secondary AC	Q3SXL2
UniProt Entry Name	ASIP_HUMAN
Gene Symbol	ASIP
GeneID	434
NCBI Accession	NP_001663.2
KEGG	hsa:434
String	9606.ENSP00000454804
Molecular Weight	Calculated MW: 15 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Agouti-Signaling Protein (ASIP)

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