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Cyclic AMP-Dependent Transcription Factor ATF-1 (ATF1) Antibody
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Catalogue No: abx004436
Price:
US$203.00
(Size: 20 µl)
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ATF1 Antibody is a Rabbit Polyclonal antibody against ATF1. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-1 (ATF1)
| Target | Cyclic AMP-Dependent Transcription Factor ATF-1 (ATF1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ATF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P18846 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DRF9, P25168, Q9H4A8 |
| UniProt Entry Name | ATF1_HUMAN |
| Gene Symbol | ATF1 |
| GeneID | 466 |
| NCBI Accession | NP_005162.1 |
| KEGG | hsa:466 |
| String | 9606.ENSP00000262053 |
| Molecular Weight | Calculated MW: 29 kDa Observed MW: 36 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |