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Cyclic AMP-Dependent Transcription Factor ATF-4 (ATF4) Antibody
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Catalogue No: abx000590
Price:
US$348.00
(Size: 60 µl)
Reviews: 
(1 Publications and Reviews)
(1 Publications and Reviews)
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ATF4 Antibody is a Rabbit Polyclonal antibody against ATF4. ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-4 (ATF4)
| Target | Cyclic AMP-Dependent Transcription Factor ATF-4 (ATF4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human ATF4 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P18848 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96AQ3, Q9UH31 |
| Gene Symbol | ATF4 |
| GeneID | 468 |
| NCBI Accession | NP_001666.2 |
| KEGG | hsa:468 |
| String | 9606.ENSP00000336790 |
| Molecular Weight | Calculated MW: 38 kDa Observed MW: 50 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
