Ubiquitin-Like Protein ATG12 (ATG12) Antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.

Target	Ubiquitin-Like Protein ATG12 (ATG12)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/50 - 1/100, IF/ICC: 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ATG12.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O94817 (UniProt, ExPASy)
UniProt Secondary AC	Q6PJV2
UniProt Entry Name	ATG12_HUMAN
Gene Symbol	ATG12
GeneID	9140
OMIM	609608
NCBI Accession	NP_001264712.1 NP_004698.3
HGNC	588
KEGG	hsa:9140
Ensembl	ENSG00000145782
String	9606.ENSP00000425107
Molecular Weight	Calculated MW: 15.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ubiquitin-Like Protein ATG12 (ATG12)

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