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Autophagy-Related Protein 13 (ATG13) Antibody
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Catalogue No: abx000825
Price:
US$203.00
(Size: 20 µl)
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ATG13 Antibody is a Rabbit Polyclonal antibody against ATG13. The autophagy-related protein 13 (Atg13) plays an important role in the formation of autophagosomes. Autophagosomes are formed in response to nutrient deprivation and function as the transport vesicles for organelles, proteins, and protein complexes targeted for lysosomes that digest these cargos to produce energy and nutrients. Atg13 is activated by the mTOR pathway and forms a complex with the FIP200 protein. This complex is involved in enhancing the activity of the ULK1 kinase which is required for the formation of autophagosomes. Atg13/FIP200 faciliates the localization of ULK1 to pre-autophagosomes, and subsequently stabilizes ULK1. Autophagy is an important process in development, growth, and cell differentiation, and disruption of this process may contribute to cancer, aging, and neurodegenerative diseases.
Research Articles on Autophagy-Related Protein 13 (ATG13)
| Target | Autophagy-Related Protein 13 (ATG13) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 281-480 of human ATG13. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O75143 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DFI4, D3DQQ1, D3DQQ2, E9PQZ8, Q53EN6, Q9BRL3, Q9H8B0 |
| UniProt Entry Name | ATG13_HUMAN |
| Gene Symbol | ATG13 |
| GeneID | 9776 |
| NCBI Accession | NP_001136145.1 |
| KEGG | hsa:9776 |
| String | 9606.ENSP00000432412 |
| Molecular Weight | Calculated MW: 57 kDa Observed MW: 72 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |