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Autophagy Related 4C Cysteine Peptidase (ATG4C) Antibody
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Catalogue No: abx030028
Price:
US$326.25
(Size: 80 µl)
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Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE) conjugated form, and has the capacity for the binding to autophagosomes.
Research Articles on Autophagy Related 4C Cysteine Peptidase (ATG4C)
| Target | Autophagy Related 4C Cysteine Peptidase (ATG4C) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 419-448 amino acids from the C-terminal region of human ATG4C. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96DT6 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NLR8, D3DQ58, Q96K04 |
| UniProt Entry Name | ATG4C_HUMAN |
| NCBI Accession | NP_116241.2 NP_835739.1 |
| KEGG | hsa:84938 |
| String | 9606.ENSP00000322159 |
| Molecular Weight | Calculated MW: 52.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |