Autophagy Related Protein 7 (ATG7) Antibody

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Catalogue No: abx030055
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Target Autophagy Related Protein 7 (ATG7)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500, IHC-P: 1/1000, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7.
Isotype IgG
Form Liquid
Purification Purified Rabbit Polyclonal Antibody.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O95352 (UniProt, ExPASy)
UniProt Secondary AC B4E170, E9PB95, Q7L8L0, Q9BWP2, Q9UFH4
UniProt Entry Name ATG7_HUMAN
NCBI Accession NP_001129503.2 NP_001138384.1 NP_006386.1
KEGG hsa:10533
String 9606.ENSP00000346437
Molecular Weight Calculated MW: 78 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Rat and Chicken ATG7.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Autophagy Related Protein 7 (ATG7)


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