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Autophagy Related Protein 7 (ATG7) Antibody
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Catalogue No: abx030055
Price:
US$326.25
(Size: 80 µl)
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Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
Research Articles on Autophagy Related Protein 7 (ATG7)
| Target | Autophagy Related Protein 7 (ATG7) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/1000, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95352 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E170, E9PB95, Q7L8L0, Q9BWP2, Q9UFH4 |
| UniProt Entry Name | ATG7_HUMAN |
| NCBI Accession | NP_001129503.2 NP_001138384.1 NP_006386.1 |
| KEGG | hsa:10533 |
| String | 9606.ENSP00000346437 |
| Molecular Weight | Calculated MW: 78 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Chicken ATG7. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |