ATM (pS1981) Antibody

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Catalogue No: abx032012
Price: US$326.25
(Size: 80 µl)
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ATM (pS1981) Antibody
ATM (pS1981) Antibody ATM (pS1981) Antibody

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Datasheet SDS
ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.

Target ATM (pS1981)
Clonality Polyclonal
Target Modification Ser1981
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, IF/ICC, DB
Host Rabbit
Recommended dilutions IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13315 (UniProt, ExPASy)
UniProt Secondary AC B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7
UniProt Entry Name ATM_HUMAN
KEGG hsa:472
String 9606.ENSP00000278616
Molecular Weight Calculated MW: 351 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on ATM (pS1981)
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