ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Antibody

This gene encodes one of the SERCA Ca (2+) ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 374-403 amino acids from the Central region of human ATP2A2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P16615 (UniProt, ExPASy)
UniProt Secondary AC	A6NDN7, B4DF05, P16614, Q86VJ2
UniProt Entry Name	AT2A2_HUMAN
Gene Symbol	ATP2A2
KEGG	hsa:488
String	9606.ENSP00000440045
Molecular Weight	Calculated MW: 115 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)

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