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ATPase, Cu++ Transporting Beta Polypeptide (ATP7B) Antibody
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Catalogue No: abx146776
Price:
US$406.00
(Size: 100 µg)
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ATPase, Cu++ Transporting Beta Polypeptide (ATP7B) Antibody is a Rabbit Polyclonal antibody for the detection of ATP7B. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Research Articles on ATPase, Cu++ Transporting Beta Polypeptide (ATP7B)
| Target | ATPase, Cu++ Transporting Beta Polypeptide (ATP7B) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ATP7B |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P35670 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16318, Q16319, Q4U3V3, Q59FJ9, Q5T7X7 |
| UniProt Entry Name | ATP7B_HUMAN |
| Gene Symbol | ATP7B |
| GeneID | 540 |
| OMIM | 277900 |
| HGNC | 870 |
| KEGG | hsa:540 |
| Ensembl | ENSG00000123191 |
| String | 9606.ENSP00000242839 |
| Molecular Weight | Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |