ATPase, Cu++ Transporting Beta Polypeptide (ATP7B) Antibody

ATPase, Cu++ Transporting Beta Polypeptide (ATP7B) Antibody is a Rabbit Polyclonal antibody for the detection of ATP7B.

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Target	ATPase, Cu++ Transporting Beta Polypeptide (ATP7B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	IHC
Host	Rabbit
Recommended dilutions	IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	ATP7B
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P35670 (UniProt, ExPASy)
UniProt Secondary AC	Q16318, Q16319, Q4U3V3, Q59FJ9, Q5T7X7
UniProt Entry Name	ATP7B_HUMAN
Gene Symbol	ATP7B
GeneID	540
OMIM	277900
HGNC	870
KEGG	hsa:540
Ensembl	ENSG00000123191
String	9606.ENSP00000242839
Molecular Weight	Observed MW: 30 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on ATPase, Cu++ Transporting Beta Polypeptide (ATP7B)

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