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Serine/Threonine-Protein Kinase ATR (ATR) Antibody
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Catalogue No: abx005469
Price:
US$348.00
(Size: 60 µl)
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ATR Antibody is a Rabbit Polyclonal antibody against ATR. The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Research Articles on Serine/Threonine-Protein Kinase ATR (ATR)
| Target | Serine/Threonine-Protein Kinase ATR (ATR) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human ATR |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13535 (UniProt, ExPASy) |
| UniProt Secondary AC | Q59HB2, Q7KYL3, Q93051, Q9BXK4 |
| UniProt Entry Name | ATR_HUMAN |
| Gene Symbol | ATR |
| GeneID | 545 |
| NCBI Accession | NP_001175.2 |
| KEGG | hsa:545 |
| String | 9606.ENSP00000343741 |
| Molecular Weight | Calculated MW: 294 kDa/297 kDa/301 kDa Observed MW: 301 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
