+44 (0) 1223 755950
+1 832 327 7413
Aurora Kinase A (AURKA) Antibody
REQUEST MORE INFO
Catalogue No: abx001733
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.
Research Articles on Aurora Kinase A (AURKA)
| Target | Aurora Kinase A (AURKA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 301-403 of human AURKA. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14965 (UniProt, ExPASy) |
| UniProt Secondary AC | E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5 |
| UniProt Entry Name | AURKA_HUMAN |
| Gene Symbol | AURKA |
| GeneID | 6790 |
| OMIM | 603072 |
| NCBI Accession | NP_003591.2 |
| HGNC | 11393 |
| KEGG | hsa:6790 |
| Ensembl | ENSG00000087586 |
| String | 9606.ENSP00000216911 |
| Molecular Weight | Calculated MW: 46 kDa Observed MW: 46 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 7.97 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |