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Axin-2 (AXIN2) Antibody
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Catalogue No: abx001955
Price:
US$348.00
(Size: 60 µl)
Click on the image to see the image legend
Axin-2 (AXIN2) Antibody is a Rabbit Polyclonal antibody against Axin-2 (AXIN2). The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Research Articles on Axin-2 (AXIN2)
| Target | Axin-2 (AXIN2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | IHC |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human AXIN2 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y2T1 (UniProt, ExPASy) |
| UniProt Secondary AC | Q3MJ88, Q9H3M6, Q9UH84 |
| UniProt Entry Name | AXIN2_HUMAN |
| Gene Symbol | AXIN2 |
| GeneID | 8313 |
| OMIM | 114500 |
| NCBI Accession | NP_004646.3 |
| HGNC | 904 |
| Ensembl | ENSG00000168646 |
| String | 9606.ENSP00000302625 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
