B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody is a Rabbit Polyclonal antibody for the detection of CD79A.

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Target	B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	CD79a molecule, immunoglobulin-associated alpha
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P11912 (UniProt, ExPASy)
UniProt Secondary AC	A0N775, Q53FB8
UniProt Entry Name	CD79A_HUMAN
Gene Symbol	CD79A
GeneID	973
OMIM	112205
HGNC	1698
KEGG	hsa:973
Ensembl	ENSG00000105369
String	9606.ENSP00000221972
Molecular Weight	Observed MW: 40 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue