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Beta-Secretase 1 (BACE1) Antibody
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Catalogue No: abx033674
Price:
US$326.25
(Size: 80 µl)
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Research Articles on Beta-Secretase 1 (BACE1)
| Target | Beta-Secretase 1 (BACE1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P56817 (UniProt, ExPASy) P56818 (UniProt, ExPASy) |
| UniProt Secondary AC | A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1 |
| UniProt Entry Name | BACE1_HUMAN |
| Gene Symbol | BACE1 |
| GeneID | 23621 |
| OMIM | 604252 |
| NCBI Accession | NP_001193978.1 NP_036236.1 NP_620427.1 NP_620428.1 NP_620429.1 |
| HGNC | 933 |
| KEGG | hsa:23621 |
| Ensembl | ENSG00000186318 |
| String | 9606.ENSP00000318585 |
| Molecular Weight | Calculated MW: 55.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Cow BACE1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |