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bACE1 (pS498) Antibody
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Catalogue No: abx031829
Price:
US$326.25
(Size: 80 µl)
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is bACE1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Research Articles on bACE1 (pS498)
| Target | bACE1 (pS498) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | IHC |
| Host | Rabbit |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P56817 (UniProt, ExPASy) |
| UniProt Entry Name | BACE1_HUMAN |
| KEGG | hsa:23621 |
| String | 9606.ENSP00000318585 |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |