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BAG Family Molecular Chaperone Regulator 4 (BAG4) Antibody
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Catalogue No: abx028746
Price:
US$326.25
(Size: 80 µl)
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BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
Research Articles on BAG Family Molecular Chaperone Regulator 4 (BAG4)
| Target | BAG Family Molecular Chaperone Regulator 4 (BAG4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95429 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E217, O95818 |
| UniProt Entry Name | BAG4_HUMAN |
| Gene Symbol | BAG4 |
| GeneID | 9530 |
| OMIM | 603884 |
| HGNC | 940 |
| KEGG | hsa:9530 |
| Ensembl | ENSG00000156735 |
| String | 9606.ENSP00000287322 |
| Molecular Weight | Calculated MW: 49.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse BAG4. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |