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Ubiquitin Carboxyl-Terminal Hydrolase BAP1 (BAP1) Antibody
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Catalogue No: abx005012
Price:
US$348.00
(Size: 60 µl)
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BAP1 Antibody is a Rabbit Polyclonal antibody against BAP1. This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase BAP1 (BAP1)
| Target | Ubiquitin Carboxyl-Terminal Hydrolase BAP1 (BAP1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human BAP1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92560 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K993, Q6LEM0, Q7Z5E8 |
| UniProt Entry Name | BAP1_HUMAN |
| Gene Symbol | BAP1 |
| GeneID | 8314 |
| NCBI Accession | NP_004647.1 |
| KEGG | hsa:8314 |
| String | 9606.ENSP00000417132 |
| Molecular Weight | Calculated MW: 80 kDa Observed MW: 80 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
